Table 3.
Association between centrosome amplification level and prognostic factors of breast carcinoma
| Variable | Cases (n) | Centrosome amplification, mean ± standard deviation (%) | |||
| Structural | P value | Numerical | P value | ||
| Tumor size | |||||
| ≤2 cm | 40 | 4.01 ± 3.52 | 0.97 | 5.09 ± 3.05 | 0.50 |
| >2 cm | 32 | 3.98 ± 2.98 | 4.65 ± 2.25 | ||
| Nodal status | |||||
| Negative | 37 | 4.17 ± 3.59 | 0.60 | 5.24 ± 2.99 | 0.26 |
| Positive | 37 | 3.77 ± 2.88 | 4.53 ± 2.31 | ||
| Histological grade | |||||
| Grade 1 | 12 | 4.03 ± 3.83 | 5.10 ± 1.90 | ||
| Grade 2 | 50 | 3.67 ± 3.07 | 0.69 | 5.08 ± 2.90 | 0.98 |
| Grade 3 | 10 | 5.26 ± 3.60 | 0.11 | 3.65 ± 2.35 | 0.13 |
| ER status | |||||
| Positive | 52 | 3.26 ± 2.82 | 0.003 | 5.31 ± 2.72 | 0.03 |
| Negative | 23 | 5.60 ± 3.51 | 3.84 ± 2.30 | ||
| PR status | |||||
| Positive | 63 | 3.6 ± 2.8 | 0.056 | 5.17 ± 2.71 | 0.02 |
| Negative | 12 | 6.2 ± 4.3 | 3.22 ± 1.74 | ||
| HER2/neu overexpression | |||||
| Positive | 14 | 6.09 ± 3.97 | 0.005 | 4.01 ± 2.08 | 0.19 |
| Negative | 61 | 3.49 ± 2.84 | 5.05 ± 2.76 | ||
| DNA ploidy | |||||
| Diploidy | 7 | 5.21 ± 3.81 | 4.07 ± 2.13 | ||
| Aneuploidy | 31 | 4.40 ± 3.59 | 0.59 | 5.10 ± 2.86 | 0.36 |
| Multiploidy | 6 | 3.01 ± 3.62 | 0.40 | 5.37 ± 2.07 | 0.83 |