Table 2.
Gene | Number of cases studied | Methylation level (mean ± SD) (Positive rate*) | ||
Normal | Cancer | pvalue** | ||
LINE1 | 90 | 68 ± 4 | 60 ± 9 | < 0.001 |
RIL | 90 | 10 ± 4 (4.5) | 27 ± 22 (57) | < 0.001 |
HIN-1 | 90 | 5 ± 3 (2.3) | 20 ± 20 (49) | < 0.001 |
RASFF1A | 90 | 3 ± 3 (3.4) | 19 ± 20 (58) | < 0.001 |
CDH13 | 90 | 3 ± 2 (0) | 14 ± 13 (44) | < 0.001 |
RARβ2 | 90 | 2 ± 1 (0) | 7 ± 12 (17) | < 0.001 |
ARHI CpG I | 32 | 30 ± 6 (0) | 47 ± 16 (49) | < 0.001 |
ARHI CpG II | 32 | 38 ± 7 (2) | 36 ± 10 (2) | 0.250 |
RIZ1 | 37 | 2 ± 2 (0) | 3 ± 4 (5) | 0.111 |
E-cadherin | 34 | 4 ± 3 (3) | 4 ± 4 (9) | 0.163 |
p16 | 33 | 2 ± 1 (0) | 1 ± 1 (0) | 0.044 |
hMLH1 | 33 | 2 ± 3 (6) | 1 ± 1 (0) | 0.864 |
14-3-3 σ | 10 | 75 ± 21 | 60 ± 28 | 0.275 |
NKD2 | 47 | 2 ± 4 (2) | 4 ± 7 (8.5) | 0.308 |
PGRB | 48 | 3 ± 2 (0) | 2 ± 3 (0) | 0.594 |
ERα | 40 | 7 ± 4 (3) | 5 ± 3 (5) | < 0.001 |
*Positive rate using the sample mean plus two times the SD of the pooled normal samples (and minimum 10% methylation) as a cut-off point.
**p value computed using the Wilcoxon signed rank test for paired data. SD, standard deviation.