Table 1.

Randomized excision margin trials

				Recurrence		Hazard Ratio for Survival (95% confidence interval)
Study	N	Primary Thickness	Arms (cm)	Local	Nodal	Disease-Free	Overall
Veronesi et al5	612	≤ 2 mm	1 vs. 3	NS		NS	NS
Cohn-Cedermark et al8	989	≤ 2 mm	2 vs. 5	NS	NS	1.02 (0.80–1.30)	0.96 (0.75–1.24)
Khayat et al9	337	≤ 2.1 mm	2 vs. 5	NS	NS	NS	NS
Balch et al6	486	1–4 mm	2 vs. 4	NS			NS
Thomas et al7	900	>2 mm	1 vs. 3	NS	NS	1.26 (1.00–1.59)*	1.21 (0.99–1.46)

^*locoregional recurrence