Figure 1.

Disulfide connectivities reported for the SMB domain of human vitronectin. Three different disulfide connectivities have been assigned experimentally for the SMB domain—SMB-1: connectivity determined biochemically after partial reduction of refolded SMB produced in E. coli (Kamikubo et al. 2002); SMB-2: connectivity determined by X-ray crystallography of refolded SMB produced in E. coli (Zhou et al. 2003); and SMB-3: connectivity determined biochemically after partial reduction of SMB derived from plasma vitronectin by CNBr cleavage (Horn et al. 2004).