Figure 4.

Versican–LacZ expression in postnatal skin of transgenic mice. (a) Newborn skin. LacZ staining in DP (arrowheads); faint LacZ in the upper dermis (asterisk). Mouse versican in situ hybridization (inner box); specific versican mRNA signal in DP (arrow). (b) Late-anagen hair follicle; all DP cells are still LacZ positive but the volume of DP decreases (arrowheads). (c) Catagen-to-telogen hair follicle—club hair shows no LacZ staining and faint LacZ activity in the second-germ DP (arrowhead). Asterisks show melanin pigmentation in the hair shaft. (d) Anagen hair follicle in the second hair cycle. Strong LacZ staining reappears in the DP (arrowhead). (Bar = 100 μm.)