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Skeletal phenotypes of Npr3 +/+ and −/− mice. (a) Wild-type (left) and homozygous mutant mice (right) at 2 months of age. (b–e) Soft x-ray analysis of phalanges [wild type (b) and homozygous mutant (c)] and lower bodies [wild type (d) and homozygous mutant (e)] of mice at 3 months of age. (f) Body and bone dimensions of homozygous mutants at 3 months of age as percent difference from the wild type. ∗, P versus wild type < 0.001.
