Table 1.

Physiological and biochemical data

	Npr3 genotype
	+/+	+/−	−/−
ANP half-life, min	1.44  ±  0.05	N.D.	2.40  ±  0.08*
Plasma ANP, pg/ml	114.5  ±  5.9	89.5  ±  13.4	88.5  ±  9.0†
Plasma BNP, pg/ml	21.6  ±  3.8	23.4  ±  4.9	22.1  ±  1.9†
BP, mmHg	118.7  ±  1.9	118.0  ±  1.8	110.4  ±  2.3‡
Hct, %	49.9  ±  1.0	51.8  ±  0.9§	53.6  ±  0.9§
HGB, g/dl	15.6  ±  0.2	16.2  ±  0.2§	16.7  ±  0.2§
RBC, 106/mm3	9.7  ±  0.1	10.1  ±  0.3§	10.4  ±  0.1§
Water intake, ml/day	3.0  ±  0.2	3.2  ±  0.4	3.9  ±  0.3
Urine output, ml/day	1.1  ±  0.1	1.4  ±  0.1¶	2.0  ±  0.1¶
Urine cGMP, nmol/day	3.2  ±  0.3	6.5  ±  0.6‡	10.9  ±  1.4*

Data are means ± standard error using at least four males. N.D., not determined; BP, blood pressure; Hct, hematocrit; HGB, hemoglobin; RBC, red blood cells. 

^*P versus +/+ <0.0001. 

^†P versus +/+ > 0.8. 

^‡P versus +/+ <0.05. 

^§P < 0.01 by a correlation/permutation test (P-stat, see Materials and Methods) for effect of genotype on variable. 

^¶P < 0.0001, also by P-stat.