. Author manuscript; available in PMC: 2009 Jan 1.

Published in final edited form as: Mol Pharmacol. 2007 Oct 19;73(1):260–269. doi: 10.1124/mol.107.041764

Table 1.

Effect of chemotherapeutic agents on MEF cell viability (IC₅₀). MEF (Hmgb1^+/+ vs. Hmgb1⁻^/⁻) were incubated with different drug concentrations for 5 days, and viability was measured by MTT assay.

Drug	IC₅₀, μM^a
Drug	Hmgb1^+/+ MEF	Hmgb1^−/− MEF
Mercaptopurine	0.8±0.12	8.9±0.65
Thioguanine	0.5±0.11	2.2±0.29
Cytarabine	0.4±0.02	1.7±0.08
Fluorouracil	1.3±0.35	6.2±0.17
Fludarabine	2.9±0.13	4.3±0.21
Cladribine	1.9±0.29	2.91±0.16
Gemcitabine	0.02±0.001	0.02±0.005
Clofarabine	0.6±0.15	0.7±0.07

Each point is mean of 3 replicates and error bars represent ±SD, p < 0.05.