Figure 1.

The FHIT locus: intron 3 through intron 7. The hatched bar on the right represents the 180-kb sequenced region that covers 120 kb of intron 4 and 60 kb of intron 3 but not the t(3;8) chromosome translocation break. The hatched bar on the left shows the 400-kb sequence that covers 360.9 kb of intron 5, 2.6 kb of intron 6, and 36.5 kb of intron 7. The closed bars represent the five BACs that were sequenced to assemble the complete sequence. AF020503, U66722, and AF023461 are GenBank accession numbers for the previously sequenced portions of FRA3B. The loci shown across the top were placed on the map by sequence homology.