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. 1999 Jun 22;96(13):7467–7472. doi: 10.1073/pnas.96.13.7467

Figure 6.

Figure 6

UBC9 restores activation of a promoter repressed by TEL. NIH 3T3 cells were cotransfected with plasmids as indicated, and normalized CAT activities are shown. (A) TEL (bar 3) represses the promoter, whereas UBC9 (bar 2) has no effect. Cotransfection of NIH 3T3 cells with TEL and with increasing amounts of UBC9 restores promoter activity (bars 4–6). The Cys-93–Ser mutant of UBC9 is as effective as the w. t. UBC9 in restoring promoter activity (bar 7). (B) The effect of UBC9 is specific for TEL (bar 5), and another strong repressor, such as EGR1, is not affected (bar 4).