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. 1999 Jun 22;96(13):7473–7478. doi: 10.1073/pnas.96.13.7473

Figure 1.

Figure 1

Accumulation of intracellular lipid in the liver of fasted PPARα−/− mice. (A) Representative photograph demonstrating the appearance of livers from fasted PPARα+/+ (Left) and PPARα−/− (Right) mice. The livers were harvested rapidly from age-matched PPARα−/− and PPARα+/+ mice after a 24-h fast. The left hepatic lobes are shown. (B) Photomicrographs demonstrating the histologic appearance of the livers of PPARα−/− mice under fed and fasted conditions. Frozen tissue sections were prepared from the livers of PPARα−/− mice after a 24-h fast (FASTED) and age-matched PPARα−/− controls fed ad libitum (FED). The sections were stained with oil red O. The red droplets indicate positive staining for neutral lipid.