. Author manuscript; available in PMC: 2009 Jan 1.

Published in final edited form as: Blood Cells Mol Dis. 2007 Sep 14;40(1):122–131. doi: 10.1016/j.bcmd.2007.06.023

Table 1.

Effects of proteinase inhibitors on soluble hemojuvelin (s-hemojuvelin) release.

Proteinase inhibitor	Abbreviation	Concentration	s-hemojuvelin release inhibition	Target proteinases
Furin convertase inhibitor	FCI	100 nM	Yes	Furin-like proprotein convertases
Tumor necrosis factor α protease inhibitor-2	TAPI-2	50 μM	No	Metalloproteinases (MMPs and ADAMs)
1,10-Phenanthroline	PNT	25 μM	Yes^*	Metalloproteinases (MMPs and ADAMs)
Matrix metalloproteinase inhibitor 1	MMPI-1	50 μM	No	MMPs (MMP-1, MMP-3, MMP-8, and MMP-9)
Matrix metalloproteinase inhibitor 2	MMPI-2	25 μM	Yes^*	Metalloproteinases (MMPs and ADAMs)

Also showed decrease in cell-associated GPI-hemojuvelin protein level