Table 2.
Correlation between inhibition of HIV-1 (Bal)-mediated fusion and CD4–CCR5 interactions by anti-CCR5 mAbs
| mAb | Fusion inhibition, % | CD4–CCR5 inhibition, % |
|---|---|---|
| None | 0 | 0 |
| 5C7 | 0 | 0 |
| 5C7 + 2D7 | 49 | 40 |
| m180 | 0 | 0 |
| m180 + m181 | 7 | 12 |
| m180 + m182 | 16 | 10 |
| m180 + m183 | 2 | 0 |
A mixture of the anti-CCR5 mAb 5C7 with 2D7 or m180 with m181, m182, or m183 (3 μg/ml for each antibody) was used. The signal intensity for each CD4 band is presented as a percentage of the signal produced in the absence of inhibiting antibody.