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. Author manuscript; available in PMC: 2008 Jan 21.
Published in final edited form as: Br J Nutr. 2007 Apr 12;97(6):1064–1073. doi: 10.1017/S000711450769196X

Fig. 1.

Fig. 1

mRNA expression of DNA methyltransferases (Dnmt (s)) in liver from 34 day-old offspring of rats fed either a control or protein-restricted (PR), or the PR diet supplemented with folic acid (PRF) diet during pregnancy. Data from RT PCR analysis are mean (SEM) relative to the control group (n 5 per maternal dietary group). (A) Dnmt1 expression. (B) Dnmt3a expression. (C) Dnmt3b expression. Statistical comparisons were by 1-Way ANOVA with Bonferroni’s post hoc analysis. 1-Way ANOVA showed a significant difference (P<0.05) between groups for Dnmt1, but not for the other DNA methyltransferases. *P<0.05 compared to the control group. (D) Expression of the methyl binding domain protein-2 from 34 day-old offspring of rats fed either a control or PR diet. Data are mean (SEM) relative to the control group (n 5 per maternal dietary group). Statistical analysis was by Student’s unpaired t-test. (E) Binding of Dnmt1 at the glucocorticoid receptor 110 promoter in liver from 34 day-old offspring of rats fed either a control or PR diet measured by chromatin immunoprecipitation assay. Data are mean (SEM) relative to the control group (n 5 per maternal dietary group). Statistical analysis was by Student’s unpaired t-test. *P < 0.05 compared to the control group.