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. Author manuscript; available in PMC: 2008 Jan 22.
Published in final edited form as: Br J Nutr. 2007 Mar 7;97(6):1036–1046. doi: 10.1017/S0007114507682920

Fig. 3.

Fig. 3

The effect of feeding a protein-restricted diet during pregnancy in rats and mice on the methylation status of promoters in the offspring. (A) PPARα promoter methylation status and (B) glucocorticoid receptor (GR) promoter methylation status in the heart of rat offspring on postnatal day 34. (C) PPARα methylation status in rat umbilical cord at post-conceptual day 20. (D) GR promoter methylation status in mouse liver at 3 months after birth. Maternal dietary groups were Control, 18% (w/w) protein; protein-restricted (PR), 9% (w/w) protein; the PR diet supplemented with 5-fold more folic acid (RF). Analysis of promoter methylation was as described by Lillycrop et al. (2005).