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. 2008 Jan 22;6(1):e18. doi: 10.1371/journal.pbio.0060018

Figure 1. The Reverse (Reductive) Citric Acid Cycle.

Figure 1

Only the carbon species are shown, but the cycle also consumes four molecules of H2 and generates two molecules of H2O per turn. The main cycle (reactions 1–9) becomes autocatalytic if coupled to an epicycle that returns acetate to oxaloacetate (reactions 10 and 11).