Figure 1.

Domain structure of calsenilin (A) and sequence alignment of calsenilin homolog proteins in the EF3–4 region (B). Calsenilin is also known as DREAM or KChIP3. The α-helices (rectangles) and β-strands (arrows) for calsenilin EF3–4 are indicated above the sequence. (Red) The two conserved proline residues located in a loop between α2- and α3-helices. The accession numbers are Q9Y2W7 for human calsenilin, Q9NZI2 for human KChIP1, Q9NS61 for human KChIP2, Q6PIL6 for human KChIP4, AAF01804 for human frequenin, AAK34951 for human neurocalcin, and NP_002894 for human recoverin.