Figure 7.
GHB has no effect on the post-synaptic NMDA currents evoked by direct pressure application of NMDA. (A) Average traces of whole cell currents elicited by puffing 0.5 mM NMDA onto the dendrites of recorded cell before, during bath application of 1 mM GHB and during 10 μM CGP 62349 are shown. APV (50μM completely blocked NMDA-evoked currents. Scale bar: 10s/50pA.
(B) Bar graph showing that GHB has no effect the mean amplitudes of APV-sensitive NMDA-induced whole cell currents (n=6, paired t-test p>0.05).