Table 1.
Numbers of human genes, pseudogenes and gene families in each homeobox gene class. The human homeobox gene superclass contains a total of 235 probable functional genes and 65 probable pseudogenes. These are divided between 102 gene families, which are in turn divided between eleven gene classes.
Class | Subclass | Number of gene families | Number of genes | Number of pseudogenes |
ANTP | HOXL | 14 | 52 | 0 |
NKL | 23 | 48 | 19b | |
PRD | PAX | 3 | 7a | 0 |
PAXL | 28 | 43 | 24c, d | |
LIM | 6 | 12 | 0 | |
POU | 7 | 16 | 8e | |
HNF | 2 | 3 | 0 | |
SINE | 3 | 6 | 0 | |
TALE | 6 | 20 | 10f | |
CUT | 3 | 7 | 3g | |
PROS | 1 | 2 | 0 | |
ZF | 5 | 14 | 1h | |
CERS | 1 | 5i | 0 | |
Totals | 102 | 235a | 65b-h |
aIncludes PAX2, PAX5 and PAX8 that have a partial homeobox; excludes PAX1 and PAX9 that lack a homeobox.
bIncludes NANOGP11 that lacks a homeobox.
cExcludes intronless and repetitive DUX1 to DUX5 sequences.
dIncludes TPRX1P1 and TPRX1P2 that lack a homeobox.
eIncludes POU5F1P7 and POU5F1P8 that lack a homeobox.
fIncludes IRX4P1, TGIF2P2, TGIF2P3 and TGIF2P4 that lack a homeobox.
gIncludes CUX2P1, CUX2P2 and SATB1P1 that lack a homeobox.
hIncludes ZEB2P1 that lacks a homeobox.
iExcludes CERS1 that lacks a homeobox.