Table.

Characteristics of 28 RCTs Included in Primary and Secondary Analyses

Source	SSRIs Used	Randomization, SSRI:Placebo, No.	Setting	Severity Criterion *	Notes
Wade et al,16 2002	Escitalopram	191:189	Primary care	MADRS 22-40	None
Bech et al,28 2004	Escitalopram, citalopram	369:122	Outpatient	MADRS (10) ≥22	Secondary analysis only
Gorman et al,29 2002	Escitalopram, citalopram	923:398	Outpatient	MADRS ≥22	Data from 3 RCTs
Lepola et al,30 2003	Escitalopram, citalopram	315:154	Primary care	MADRS 22-40	Secondary analysis only
Andreoli et al,31 2002	Fluoxetine	127:128	Inpatient and outpatient	HDRS (21) ≥22	Secondary analysis only
Byerley et al,32 1988	Fluoxetine	32:29	Outpatient	HDRS (21) ≥20	None
Feighner et al,14 1989	Fluoxetine	61:59	Outpatient	HDRS (21) ≥20	None
Heiligenstein et al,33 1993	Fluoxetine	24:28	Outpatient	NA	Secondary analysis only
Rickels et al,34 1986	Fluoxetine	18:24	Outpatient	HDRS ≥20	Secondary analysis only
Silverstone and Ravindran,35 1999	Fluoxetine	119:118	Outpatient	HDRS(17) ≥20	None
Sramek et al,36 1995	Fluoxetine	72:72	Unclear	HDRS (24) ≥21	Primary analysis only
Tollefson and Holman,15 1994	Fluoxetine	962:485	Unclear	HDRS (21) ≥20	Data from 6 RCTs
Claghorn et al,13 1996	Fluvoxamine	50:50	Outpatient	NA	None
Dominguez et al,37 1985	Fluvoxamine	35:31	Outpatient	HDRS (17) ≥15	Primary analysis only
Porro et al,38 1988	Fluvoxamine	21:20	Unclear	HDRS ≥18	None
Roth et al,39 1990	Fluvoxamine	30:30	Outpatient	HDRS(17) ≥22	Primary analysis only
Walczak et al,40 1996	Fluvoxamine	400:200	Outpatient	HDRS ≥20	Secondary analysis only
Claghorn et al,41 1992	Paroxetine	170:171	Outpatient	HDRS (17) ≥18	Secondary analysis only
Claghorn,42 1992	Paroxetine	36:36	Outpatient	HDRS (17) ≥18	Primary analysis only
Edwards and Goldie,43 1993	Paroxetine	21:20	Outpatient	HDRS (17) ≥16	None
Feighner et al,44 1993	Paroxetine	241:244	Outpatient	HDRS (17) ≥18	Secondary analysis only Data from 6 RCTs
Katz et al,45 2004	Paroxetine	28:25	Inpatient	HDRS (21) ≥18	None
Kiev,46 1992	Paroxetine	38:40	Outpatient	HDRS (17) ≥18	None
Smith and Glaudin,47 1992	Paroxetine	39:38	Unclear	HDRS (17) ≥18	Primary analysis only
Trivedi et al,48 2004	Paroxetine CR	310:149	Outpatient	HDRS (17) ≥20	None
Fabre et al,49 1995	Sertraline	278:91	Unclear	HDRS (17) ≥22	None
Reimherr et al,50 1990	Sertraline	149:150	Outpatient	HDRS (18) ≥18	None
Trivedi et al,51 2001	Sertraline	237:245	Outpatient	HDRS (21) ≥18	Data from 2 RCTs Primary analysis only
Stahl,52 2000	Sertraline, citalopram	215:108	Unclear	HDRS (17) ≥22	Secondary analysis only

Abbreviations: CR, controlled release; HDRS, Hamilton Depression Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; NA, not available; RCT, randomized controlled trial; SSRI, selective serotonin reuptake inhibitor.

^*When trials required participants to reach specified scores on the HDRS or the MADRS for inclusion, these scores are noted immediately following the scale. Numbers in parentheses refer to the number of items on the scale.