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. 2004 Jan 19;199(2):255–264. doi: 10.1084/jem.20031519

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Copyright © 2004, The Rockefeller University Press

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Figure 9. — Interactive model for the pathogenesis of SLE. Pathway I, autoantibody production and activation of effector T cells and pathway II, activation of susceptibility genes and end organ damage, can be initiated independently while they interact at different levels as indicated by pathways III and IV. The interactions between these pathways lead to end organ damage.