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. 2004 Jun 7;199(11):1455–1465. doi: 10.1084/jem.20040139

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — Reversal of diabetes with expanded T_regs. (A) NOD mice with chronic diabetes were transplanted with syngeneic islets under the kidney capsule. On the day of transplantation, some recipient mice received 5 × 10⁶ NOD-expanded T_regs (n = 4) or 2 × 10⁶ BDC2.5-expanded T_regs (n = 5), and the remaining mice (n = 3) were left untreated. Blood glucose level was monitored. All islet recipients normalized blood glucose within the first day after transplantation. Results are representative of two independent experiments. (B) NOD mice with new onset diabetes (blood glucose > 300 mg/dL, n = 7) were injected with 10⁷ BDC2.5-expanded T_regs and blood glucose was monitored. Two consecutive readings of blood glucose of <250 mg/dL was considered remission of diabetes.