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. 2004 May 17;199(10):1421–1431. doi: 10.1084/jem.20040191

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Endogenous processing of an inserted HLA B8–restricted CTL epitope within EBNA1. (A) Two HLA B8⁺ LCLs and the same LCLs transfected with either the EBNA1-FLR-GFP or EBNA1ΔGA-FLR-GFP expression constructs were used as targets in a standard ⁵¹Cr-release assay to assess CTL activity to a B8-specific CTL clone, LC13. An E/T ratio of 5:1 was used in this assay. (B) C1R.B8 LCLs, C1R.B8.ICP47 LCLs, and the same LCLs infected with a recombinant adenovirus encoding full-length EBNA1 (Ad-EBNA1-FLR) were used as targets in a standard ⁵¹Cr-release assay to assess CTL activity. An HLA B8–restricted FLR-specific CTL clone, LC13, was used as an effector in this assay. An E/T ratio of 5:1 was used in this assay. These data are a representation of two separate experiments.