Table II.
Morbidity Leading to Hospitalization According to MBL Deficiency Genotype during 24 yr Follow-up
| Noncarriers
|
Heterozygotes
|
Homozygotes
|
||||||
|---|---|---|---|---|---|---|---|---|
| IncidenceN/10,000person · yr | RRa | IncidenceN/10,000person · yr | P-valueb | RRa(95% CI) | IncidenceN/10,000person · yr | P-valueb | RRa(95% CI) | |
| Any hospitalization | 644 | 1.0 | 631 | 0.39 | 0.98 (0.93–1.0) | 658 | 0.53 | 1.1 (0.96–1.2) |
| Infectious and parasitic diseases | 55 | 1.0 | 57 | 0.58 | 1.1 (0.93–1.2) | 50 | 0.48 | 0.91 (0.69–1.2) |
| Respiratory infections | 42 | 1.0 | 37 | 0.09 | 0.88 (0.76–1.0) | 40 | 0.75 | 0.96 (0.71–1.3) |
| Respiratory disorders | 51 | 1.0 | 49 | 0.53 | 0.99 (0.87–1.1) | 61 | 0.13 | 1.2 (0.97–1.6) |
| Cardiovascular disorders | 136 | 1.0 | 132 | 0.38 | 0.95 (0.87–1.0) | 162 | 0.02 | 1.2 (1.0–1.4) |
| Malignant neoplasms | 61 | 1.0 | 62 | 0.77 | 1.0 (0.90–1.1) | 65 | 0.64 | 1.0 (0.81–1.3) |
| Digestive disorders | 118 | 1.0 | 112 | 0.20 | 0.95 (0.87–1.0) | 135 | 0.10 | 1.2 (0.98–1.4) |
| Musculoskeletal disorders | 140 | 1.0 | 135 | 0.28 | 0.96 (0.89–1.0) | 140 | 0.96 | 1.0 (0.88–1.2) |
| Neuropsychiatric disorders | 57 | 1.0 | 57 | 0.85 | 0.97 (0.89–1.1) | 53 | 0.61 | 0.93 (0.71–1.2) |
a
Relative risks (RR) were adjusted for gender, age, smoking habits, systolic blood pressure, alcohol, cholesterol, body mass index, and physical inactivity.
b
P-values by log-rank test. Infectious and parasitic diseases: 001–136, 320, 323, 612–614, 620, 622, A00–B99, G00, G03–G04, N70–N73; respiratory infections: 460–486, 381–382, J00–J06, J10–J18, J20–J22, H65–H66; respiratory disorders: 490–519, J30–J98; cardiovascular disorders: 390–458, I00–I99; malignant neoplasms: 140–209, C00–C97; digestive disorders: 530–577, K20–K92; musculoskeletal disorders: 710–738, M00–M99; neuropsychiatric disorders: 290–315, 321–322, 324–358, F01–F99, G06–G98.