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. 2004 Feb 16;199(4):483–489. doi: 10.1084/jem.20031802

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — V(D)J recombinase activity in early B lineage precursors. (A) The transgenic H2-SVEX substrate contains VEX (white rectangle) driven by the murine H2K promoter (black rectangle). VEX within the substrate is initially in the antisense orientation and is flanked by V(D)J recombination signal sequences (triangles) which direct inversional recombination. (B) Bone marrow from SB110 H2-SVEX transgenic mice was stained with antibodies to Ly6C, DX5, B220, CD43, CD19, CD24, and IgM in order to examine VEX expression throughout B cell development. The percentage of cells in each region is given. The data are representative of three independent experiments.