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. 2004 Nov 1;200(9):1189–1195. doi: 10.1084/jem.20041328

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Loss of Bim increases thymus cellularity and numbers of splenic T and B cells in IL-7Rα^−/− mice. 6–10-wk-old (A, C, and D) or newborn (B) WT, Bim ^−/−, IL-7Rα^−/−, Bim ^+/− IL-7Rα^−/−, and Bim ^−/− IL-7Rα^−/− mice were killed to determine total leukocyte numbers in the thymus (A, B, and C) and spleen (D). Cell subset composition was determined by immunofluorescent staining with surface marker–specific antibodies (CD4 and CD8 for T cells and B220, CD19, and sIg for B cells) followed by flow cytometric analysis. Data are presented as means ± SD of at least five mice of each genotype.