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. 2004 Nov 15;200(10):1289–1297. doi: 10.1084/jem.20041789

Figure 3.

Figure 3.

Cytokine and chemokine secretion by splenocytes from mice with complete or T cell–specific IL-10 deficiency after stimulation by plate-bound anti-CD3 and anti-CD28 antibodies in vitro. (A) Concentrations of IFN-γ, TNF-α, IL-12, IL-6, and MCP-1 in 48-h culture supernatants of splenocytes from IL-10 FL/FL CD4-Cre+ animals (n = 9; □, unstimulated; ▪, stimulated), IL-10 FL/FL Cre controls (n = 8; ○, unstimulated; •, stimulated), and (B) in supernatants of splenocyte cultures from IL-10 D/D animals (n = 5; □, unstimulated; ▪, stimulated) and IL-10 WT/D controls (n = 5; ○, unstimulated; •, stimulated).