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. 2004 Nov 15;200(10):1257–1266. doi: 10.1084/jem.20040921

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — PED/PEA-15–mediated protection of adult NPCs from CD95-induced apoptosis. (A) Flow cytometry analysis of GFP positive NPCs transduced with empty Tween (Vector) or Tween/PED/PEA-15 antisense (PED/AS) vectors (gray), as compared with nontransduced NPCs (black). (B) Immunoblot analysis of PED/PEA-15 expression in NPCs transduced as in A, untreated or treated TNF-α, IFN-γ, and IL-1β (+Mix). (C) Caspase expression and degradation in NPCs transduced with empty Tween (Vector) or PED/AS and exposed to anti-CD95 where indicated. (D) Percentage of apoptosis in untransduced (Mock) and empty Tween (Vector) or PED/AS transduced NPCs exposed to anti-CD95 for 24 or 48 h. All samples in C and D were preincubated with TNF-α, IFN-γ, and IL-1β 48–60 h before anti-CD95 stimulation. Results shown are representative of four independent experiments with tissue-isolated embryonic and adult NPCs.