Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2004 Nov 15;200(10):1267–1278. doi: 10.1084/jem.20040500

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2004, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — BadA-dependent HIF-1 activation and secretion of proangiogenic cytokines. (a) HIF-1 activation detected by the use of a VEGF promoter luciferase reporter construct (pVEGF.4). HeLa cells were transfected before infection with B. henselae WT, Pil⁻, BadA⁻, and BadA⁻/BadA⁺ WT. Activation was determined by chemiluminescence 36 h after infection. (b) Induction of VEGF secretion upon infection of HeLa cells. Supernatants were taken 48 h after infection and analyzed by ELISA. (c) BadA-dependent secretion of proangiogenic cytokines in Hela cells. Cells were infected with B. henselae WT and BadA⁻, and the amount of secreted VEGF, IGFBP-3, ADM, and IL-8 was determined 8, 24, 48, and 72 h after infection by ELISA or RIA. *, significant difference compared with uninfected control (P < 0.01).