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. 2004 Nov 15;200(10):1243–1256. doi: 10.1084/jem.20040511

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Effect of the amino acid changes selected for in each subject's in vivo viral quasispecies on epitope-specific CD8⁺ CTL responses. The relative ability of synthetic peptides corresponding to the indicated index and variant epitope sequences to sensitize autologous target cell lines for lysis by polyclonal CTLs derived from subjects BORI (a), WEAU (b), and SUMA (c) early after infection was compared using in vitro cytotoxicity assays. The results shown are the specific lysis (% specific ⁵¹Cr release) of target cells incubated with the indicated concentrations of each peptide.