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Thymocyte migration in the absence of CCR7 signaling. In the absence of CCR7 or its ligands, DN thymocytes are retained at the cortical–medullary junction, resulting in a modest block in the later stages of thymocyte development (24). In addition, post-selected DP thymocytes are not directed into the medulla but remain in the cortex where they develop into mature SP (23).
