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. 2004 Aug 16;200(4):411–423. doi: 10.1084/jem.20040845

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Pro–B cells derived from young and aged sources display similar rag2 expression and pre:pro ratios in young hosts. Bone marrow from young (3 mo) and aged (26–27 mo) NG mice were transferred into lethally irradiated young (2 mo at time of transfer) recipient mice. (A) GFP expression in pro–B cells (left) and pre:pro ratio (right) in young and aged donor mice at time of transfer. These mice are four of the six young and all of the aged mice shown in Fig. 1. Black bars represent young donor mice, and diagonally striped bars represent aged donor mice. To aid comparisons, each young donor mouse is given a designation, Y1-Y4, and each aged donor mouse was given A1-A5, depicted below each panel. (B) Analyses of bone marrow harvested from young recipient mice 5 wk after transfer of cells from either young or aged donors. Pro–B cells were defined as IgM⁻B220⁺CD43⁺AA4.1⁺ and pre–B cells were defined as IgM⁻B220⁺CD43⁻AA4.1⁺CD24⁺. The percentage of pro–B cells that are GFP⁺ and the pre:pro ratios are shown. The pre:pro ratio of two young unmanipulated NG mice used as controls in this experiment were 1.2 and 1.3. Each bar represents values obtained from one recipient mouse. The designations Y1-Y4 and A1-A5 reflect the source of the transferred bone marrow as shown in A, and brackets show the groups of recipients according to the donor designation.