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. 2004 Dec 6;200(11):1383–1393. doi: 10.1084/jem.20040795

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Impaired S. pneumoniae trapping by SIGN-R1^−/− MZM. Wild-type (left) and SIGN-R1^−/− (right) mice were injected intravenously with 10⁷ FITC-labeled S. pneumoniae. 30 min later, spleens were snap frozen, and cryosections were prepared and counterstained with anti-MARCO antibody (Texas red) to delineate MZMs. Arrows indicate areas where S. pneumoniae are located in the red pulp and are not restricted to the MZ. FO, follicles. Original magnification, 10 (top), 20 (bottom). Representative sections from two mice per group are shown.