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. 2004 Dec 6;200(11):1427–1435. doi: 10.1084/jem.20041041

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Copyright © 2004, The Rockefeller University Press

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Figure 4. — Rapid relocalization of a CD8 gene after TCR stimulation of DPK cells. DPK cells were stimulated for 6 or 18 h by coculture with DCEK cells bearing MHC class II I-E^K and cytochrome C peptide, and analyzed by FISH. The number of alleles scored for each sample is indicated beneath each set of bars. The percent of CD69⁺ cells within each population is indicated. DPK cells from the 18-h time point were also sorted into CD69⁺ and CD69⁻ fractions before FISH analysis. After 48 h of stimulation, a substantial fraction of DPK cells down-regulate surface CD8 expression; however, at 18 h, surface levels of CD4 and CD8 remain unchanged (reference 32 and not depicted). No increase in the percent of CD4 alleles associated with centromeric heterochromatin was observed at any time point (not depicted).