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. 2004 Dec 6;200(11):1407–1417. doi: 10.1084/jem.20040717

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — CD27 surface expression and telomere length on HIV-, CMV-, and EBV-specific CD8 clones. All HIV-specific CD8 clones recognized the gag protein, with two restricted to the B57 allele, two to B8, and two to B13. Two independently generated clones were analyzed for patient numbers 15249 and 16342. Two CMV-specific T cell clones were A2 restricted and pp65 specific, one was specific for the immediate early protein with unknown restriction, and two were specific for unknown CMV proteins. All EBV-specific CD8 clones were A2-restricted and recognized the BMFL1 peptide. (A) Surface expression of CD8 clones was assessed by FACS, with the percentage of CD27⁺ cells of total T cells shown. (B) Telomere length of the same clones was analyzed by FACS. Virus copy number in plasma and CD4⁺ T cell count at the time point cells were obtained for cloning are indicated for HIV-infected patients.