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. 2004 Sep 20;200(6):771–782. doi: 10.1084/jem.20041130

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — Concomitant tumor immunity is dependent on CD8⁺ cells. C57BL/6 mice (5–15/group) were inoculated with B16 cells (A) or B16-GMCSF cells (B) in the right flank, followed 6 d later by B16 cells in the left flank. In addition, all mice received CD4-depleting antibody on days 4 and 10 to induce concomitant immunity. In each panel, the left graph depicts growth of primary tumors and the right graph depicts growth of challenge tumors in the same mice. The two bottom panels show tumor outgrowth in mice coinjected with CD8-depleting antibody (arrows). Significance for each group was determined by log rank analysis comparing growth of challenge tumors in CD8-depleted versus nondepleted mice. (A) P = 0.0892; (B) P = 0.0022.