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. 2004 Sep 20;200(6):761–770. doi: 10.1084/jem.20041196

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — CD4⁺ T cells are preferentially depleted in the GI tract in acute and early HIV-1 infection. PBMCs and MMCs from the rectosigmoid region from group 1, acute and early HIV-1 infection subjects (n = 13), and HIV-1–uninfected controls (n = 10) were analyzed by flow cytometry. CD3⁺ gated lymphocytes were analyzed for the expression of CD4 and CD8. (A) A representative flow plot from subject 105 is depicted. CD8⁺ T cells are shown on the x axis and CD4⁺ T cells are shown on the y axis. (B) Comparison of CD4⁺ T cells in the blood and GI tract of all 13 group 1 primary infection subjects. The percent of CD4⁺ T cells is shown in PBMCs (gray) and MMCs (white) per study subject. (C) Comparison of the mean percent of CD4⁺ T cells in the PBMCs of HIV-1–uninfected controls (black bar) and group1 subjects (gray bar), and MMCs of HIV-1–uninfected controls (hatched bar) and group 1 subjects (white bar).