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. 2004 Aug 2;200(3):377–389. doi: 10.1084/jem.20040104

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — Role of apoptosis in TGF-β₁–induced fibrosis and remodeling. Transgene⁻ and transgene⁺ mice were randomized to normal or dox water. After 10 d of dox, collagen content was evaluated with trichrome evaluations (A) and Sircol assays (B), and alveolar remodeling was assessed with chord length determinations (C). (A–C) Z-VAD-fmk or its vehicle control (Z-VAD-fmk (−)) was administered starting the day before the dox. (D) Z-VAD-fmk or its control was administered 5 d after the initiation of dox (*, P < 0.01) and collagen accumulation was assessed. (A) A representative of a minimum of five experiments is shown. (B–D) The values represent the mean ± SEM of evaluations in a minimum of five animals.