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. 2004 Jul 19;200(2):211–222. doi: 10.1084/jem.20032053

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Copyright © 2004, The Rockefeller University Press

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Figure 4. — Promethazine protects mice from MCA occlusion/reperfusion. (A) Total stroke volume in C57/Bl6 mice untreated and treated. P < 0.005. Means shown with SD to emphasize reduced variability of stroke volume in drug treatment, and with standard error to show accuracy of population estimate. (B) Neuro exam assessed at 24 h after reperfusion of right MCA. Mean ± SEM, P < 0.05. (C) Neuro exam assessed at 30 min after occlusion of right MCA. Mean ± SEM, P = 1.0. (D) Stroke Volume versus Neurologic Exam. Diagonal line emphasizes that all treated individuals appear protected (left of line, 13 treated, 2 control; right of line, 11 control). (inverted triangles) Promethazine treated. (dots) Controls. n = 13 in each group. Middle cerebral artery occlusion/reperfusion studies were conducted as described previously (references 60, 61).