Abstract
If genetically resistant and susceptible rabbits inhale a certain number of human type tubercle bacilli, no tuberculosis in the lungs of the resistant animals is seen, as a rule several months after infection, while there is a variable and often extensive disease in the susceptible rabbits. The analogy to the presence or absence of active tuberculosis in man infected with the tubercle bacillus is evident. The inhaled tubercle bacilli multiply for but a short time in the resistant rabbits and are usually rapidly and completely destroyed. In the susceptible rabbits, the bacilli multiply profusely for a much longer time and persist in large numbers even months after inhalation. Whatever be the cause of the more rapid destruction of tubercle bacilli in the resistant animal, the resulting more rapid release of the contained antigens enhances the development of allergic sensitivity and antibodies in these animals. The development of an acquired resistance against tubercle bacilli of the human type is sufficiently rapid to affect the genesis of the initial gross primary pulmonary foci that result from the inhalation of a given number of bacilli. The greater the genetic resistance, the fewer the initial primary foci. Variations in genetic resistance are essentially variations in the rate of development of acquired resistance. It is suggested that variations in genetic resistance to inhaled human type tubercle bacilli may affect the prevalence of alveolar phagocytes capable of acquiring adequate resistance to the growth of the bacilli in their cytoplasm. The prevalence of such cells is subject to hormonal and immunological influences.
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Selected References
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- Brown J. H., Cook K. M., Ney F. G., Hatch T. Influence of Particle Size upon the Retention of Particulate Matter in the Human Lung. Am J Public Health Nations Health. 1950 Apr;40(4):450–480. doi: 10.2105/ajph.40.4.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLDBERG L. J., LEIF W. R. The use of a radioactive isotope in determining the retention and initial distribution of airborne bacteria in the mouse. Science. 1950 Sep 15;112(2907):299–300. doi: 10.1126/science.112.2907.299. [DOI] [PubMed] [Google Scholar]
- HEPPLESTON A. G. Quantitative air-borne tuberculosis in the rabbit; the cause of human type infection. J Exp Med. 1949 Jun 1;89(6):597–610. doi: 10.1084/jem.89.6.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LURIE M. B., ABRAMSON S. Reproduction of human ulcerative pulmonary tuberculosis in rabbits by quantitative natural airborne contagion. Proc Soc Exp Biol Med. 1948 Dec;69(3):531–537. doi: 10.3181/00379727-69-16780. [DOI] [PubMed] [Google Scholar]
- LURIE M. B., HEPPLESTON A. G., ABRAMSON S., SWARTZ I. B. Evaluation of the method of quantitative airborne infection and its use in the study of the pathogenesis of tuberculosis. Am Rev Tuberc. 1950 Jun;61(6):765–797. [PubMed] [Google Scholar]
- LURIE M. B., ZAPPASODI P., DANNENBERG A. M., Jr Constitutional factors in resistance to infection; the effect of cortisone on the pathogenesis of tuberculosis. Science. 1951 Mar 2;113(2931):234–237. doi: 10.1126/science.113.2931.234. [DOI] [PubMed] [Google Scholar]
- Lurie M. B., Collaboration of Peter Zappasodi STUDIES ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS : THE FATE OF TUBERCLE BACILLI INGESTED BY MONONUCLEAR PHAGOCYTES DERIVED FROM NORMAL AND IMMUNIZED ANIMALS. J Exp Med. 1942 Mar 1;75(3):247–268. doi: 10.1084/jem.75.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. THE FATE OF BCG AND ASSOCIATED CHANGES IN THE ORGANS OF RABBITS. J Exp Med. 1934 Jul 31;60(2):163–178. doi: 10.1084/jem.60.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B. THE FATE OF HUMAN AND BOVINE TUBERCLE BACILLI IN VARIOUS ORGANS OF THE RABBIT. J Exp Med. 1928 Jul 31;48(2):155–182. doi: 10.1084/jem.48.2.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MIDDLEBROOK G., DUBOS R. J. Specific serum agglutination of erythrocytes sensitized with extracts of tubercle bacilli. J Exp Med. 1948 Nov;88(5):521–528. doi: 10.1084/jem.88.5.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Middlebrook G., Dubos R. J., Pierce C. VIRULENCE AND MORPHOLOGICAL CHARACTERISTICS OF MAMMALIAN TUBERCLE BACILLI. J Exp Med. 1947 Jul 31;86(2):175–184. doi: 10.1084/jem.86.2.175. [DOI] [PMC free article] [PubMed] [Google Scholar]