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. 1998 Jan 19;187(2):205–216. doi: 10.1084/jem.187.2.205

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The strength of LNC rolling in HEVs is not augmented by α4 or LFA-1 integrins, and is not PTX sensitive. Frequency histograms were generated by measuring rolling velocities of individual LNCs in order III venules before (control) and after treatment with (A) anti–LFA-1, (B) anti-α4, or (C) PTX or MTX. V_roll, V_fast, and V_blood were determined in the same vessels before and after mAb, MTX, or PTX treatment as described in Materials and Methods (results of hemodynamic measurements are given in Table 1). To account for hemodynamic differences between control and treatment period, V_rel was calculated as percentage of V_blood. Frequency distributions were calculated after cells were assigned to velocity classes with V_rel >0% to <1%, 1% to <2%, and so on. Statistical comparison of population means and distributions revealed no significant differences between rolling velocities (P >0.05).

The strength of LNC rolling in HEVs is not augmented by α4 or LFA-1 integrins, and is not PTX sensitive. Frequency histograms were generated by measuring rolling velocities of individual LNCs in order III venules before (control) and after treatment with (A) anti–LFA-1, (B) anti-α4, or (C) PTX or MTX. V_roll, V_fast, and V_blood were determined in the same vessels before and after mAb, MTX, or PTX treatment as described in Materials and Methods (results of hemodynamic measurements are given in Table 1). To account for hemodynamic differences between control and treatment period, V_rel was calculated as percentage of V_blood. Frequency distributions were calculated after cells were assigned to velocity classes with V_rel >0% to <1%, 1% to <2%, and so on. Statistical comparison of population means and distributions revealed no significant differences between rolling velocities (P >0.05).