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. 1998 Jan 19;187(2):147–159. doi: 10.1084/jem.187.2.147

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Defective antibody response to T-dependent antigens in p52-deficient mice. 5–30-wk-old mice of both sexes were injected intraperitoneally with (A) 100 μg of TNP (2,4,6 trinitro-phenyl)–KLH (TD), (B) 25 μg of TNP-Ficoll (TI-2) or (C) 50 μg of TNP-LPS (TI-1). Serum levels of anti-TNP specific antibodies were determined by isotype-specific ELISA 14 d after injection of the TNP conjugates. Antibody levels, expressed as OD, are shown for each genotype, as indicated. Anti-TNP antibodies were undetectable in sera of animals before challenge (data not shown). OD values differed significantly among the following groups of animals by one-way analysis of variance. (A) (−/−) versus (+/+) all isotypes tested; (−/−) versus (+/−), IgM, IgG1, IgG2b and IgG3; (+/−) versus (+/+), IgG1, IgG2a, IgG2b. (C) (−/−) versus (+/−) and (+/+), IgM, and IgG1. All other groups were not significantly different.