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Germinal centers and B cell follicles are absent in spleens of p52 (−/−) mice, but are present in p50 (−/−) mice. Analyses of spleens taken from an unchallenged, 21-wk-old p52/p10 (−/−) mouse, a (+/−) littermate control (top and middle, respectively), and an unchallenged 15-wk-old p50/ p105 (−/−) mouse (bottom). Bouin-fixed, paraffin-embedded sections were processed with anti-CD3 or anti-B220 antibodies, as indicated.
