Table 1.

Susceptibility of IL-4^−/− and IL-4^{+ /+} Mice to C. albicans Infection

Mice		Primary infection										Secondary infection*
		Yeast		Dose		Route		MST		D/T		Yeast		Dose		Route		MST		D/T
IL-4−/−		CA-6		106		i.v.		4		8/8		–		–		–		–		–
		CA-6		5 × 105		i.v.		16†		8/8		–		–		–		–		–
		CA-6		2 × 105		i.v.		>60†		0/8		CA-6		106		i.v.		5.5		4/4
		CA-6		108		i.g.		>60		0/8		CA-6		5 × 105		i.v.		10		4/4
		PCA-2		106		i.v.		>60		0/12		CA-6		106		i.v.		6		6/6
IL-4+/+		CA-6		106		i.v.		5		12/12		–		–		–		–		–
		CA-6		5 × 105		i.v.		7		8/8		–		–		–		–		–
		CA-6		2 × 105		i.v.		15		8/8		–		–		–		–		–
		CA-6		108		i.g.		>60		0/12		CA-6		5 × 105		i.v.		21		6/6
		PCA-2		106		i.v.		>60		0/12		CA-6		106		i.v.		>60		0/6

i.g., intragastric; MST, median survival time (d); D/T, dead animals over total mice infected.  

^* Surviving mice were reinfected 14 d after the primary challenge.  

^†  P < 0.05, Mann Whitney U test (IL-4^−/− versus IL-4^+/+).