Table 1.

Cytokine Secretion by Splenocytes Challenged with SEA (pg/ml)

		IL-4		IL-5		IL-10		IL-2		IFN-γ
MCP-1+/+ (4)		58 ± 12		2100 ± 540		276 ± 88		492 ± 96		1953 ± 544
MCP-1−/− (4)		11 ± 1.6		1000 ± 190		288 ± 43		510 ± 63		820 ± 176
P value		0.028		0.048		NS		NS		0.08

Mice were sensitized with SEA and spleens were harvested 2 wk later. Splenocytes were challenged in vitro with SEA and the concentration of indicated cytokine in conditioned medium was determined 24 h later by ELISA. Numbers in parentheses indicate the number of mice tested. P values were determined by Student's t test.