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DIL-6−/− mice have abnormal humoral response to type II collagen. DIL-6+/+ (black bars; n = 9) and DIL-6−/− (white bars; n = 8) mice were bled 10 wk after the first immunization with CII, and levels of anti-CII antibodies were measured by ELISA. (A) Total IgG anti-CII antibodies were reported as mean ± SD (*P <0.02). (B) Isotype percentages of total IgG antibodies anti-CII were reported as mean ± SD. IgG isotypes are indicated.
