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. 1998 Mar 16;187(6):917–928. doi: 10.1084/jem.187.6.917

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Hepatic injury in wild-type (WT) and iNOS knockout (KO) mice subjected to hemorrhagic shock. The release of the hepatocellular enzyme ALT into plasma was used as an index of hepatic injury. ALT release (IU/liter) from shock and sham wild-type or knockout mice was measured using an autoanalyzer (RA 500; Technitron) and plotted. Values shown are mean ± SEM. Black bars, wild-type (WT) animals (n = 5); gray bars, knockout (KO) animals (n = 5). In shocked wild-type mice, ALT levels demonstrated a 40-fold increase compared to sham wild-type mice (P <0.01). In shocked knockout mice, ALT levels were reduced 80% (P <0.01) compared to shocked wild-type mice.