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. 1998 Mar 16;187(6):967–972. doi: 10.1084/jem.187.6.967

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Impaired lineage development correlates with the absence of IL-15. (A) Limited IL-15 expression in the absence of IRF-1. BM cells were isolated from IRF-1^−/− mice or control wild-type (WT) mice. Total RNA was extracted from untreated BM cells or BM cells cultured for 6 h in the presence of LPS (30 μg/ml) and IFN-γ (100 U/ml). Northern blot analysis was performed using IL-15 cDNA and β-actin probes. (B) IL-15 induces the expansion of NK1⁺T cells, NK cells, and IEL subsets. Liver MNCs and intestinal IELs were isolated from IRF-1^−/− mice and cultured with 100 ng/ml mouse IL-15 for 7 d.

Impaired lineage development correlates with the absence of IL-15. (A) Limited IL-15 expression in the absence of IRF-1. BM cells were isolated from IRF-1^−/− mice or control wild-type (WT) mice. Total RNA was extracted from untreated BM cells or BM cells cultured for 6 h in the presence of LPS (30 μg/ml) and IFN-γ (100 U/ml). Northern blot analysis was performed using IL-15 cDNA and β-actin probes. (B) IL-15 induces the expansion of NK1⁺T cells, NK cells, and IEL subsets. Liver MNCs and intestinal IELs were isolated from IRF-1^−/− mice and cultured with 100 ng/ml mouse IL-15 for 7 d.

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