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. 1998 Apr 6;187(7):1057–1067. doi: 10.1084/jem.187.7.1057

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Thapsigargin or ionomycin induction of perforin versus FasL/Fas killing. 14-7 was stimulated with 2,000, 1,000, 200, 100, 20, or 10 nM of ionomycin (a) or thapsigargin (b) and [Ca²⁺]_i was measured by indo-1 fluorescence. 14-7 was stimulated with PMA (25 ng/ml) plus different doses of ionomycin or thapsigargin, and granzyme A granule exocytosis was determined (c and d, ▪), or 14-7 was stimulated with ionomycin or thapsigargin in the absence of PMA and percentage of specific killing of the L1210Fas⁺ target was determined (c and d, ○).