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Schematic diagram of FcγRIIB–PIR-B chimeric molecules. PIR-B cytoplasmic region contains four ITIM-like motifs (residues 688– 693, SLYASV; 717–722, ETYAQV; 769–774, VTYAQL; and 799–804, SVYATL). In addition to these tyrosines, the cytoplasmic domain of PIR-B contains one more tyrosine (residue 747). The open and shaded boxes represent portions of FcγRIIB and PIR-B, respectively.
